The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding.
Identifieur interne : 000021 ( Main/Exploration ); précédent : 000020; suivant : 000022The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding.
Auteurs : Jun Liu [États-Unis] ; Yanyan Huang [États-Unis, République populaire de Chine] ; Liang Kong [États-Unis] ; Xiao Yu [États-Unis] ; Baomin Feng [États-Unis] ; Derui Liu [États-Unis] ; Baoyu Zhao [États-Unis] ; Giselle C. Mendes [États-Unis, Brésil] ; Peiguo Yuan [États-Unis] ; Dongdong Ge [États-Unis] ; Wen-Ming Wang [République populaire de Chine] ; Elizabeth P B. Fontes [Brésil] ; Pingwei Li [États-Unis] ; Libo Shan [États-Unis] ; Ping He [États-Unis]Source :
- Nature plants [ 2055-0278 ] ; 2020.
Abstract
The innate immune system detects pathogen-derived molecules via specialized immune receptors to prevent infections1-3. Plant immune receptors include cell surface-resident pattern recognition receptors (PRRs, including receptor-like kinases (RLKs)), and intracellular nucleotide-binding domain leucine-rich repeat proteins (NLRs). It remains enigmatic how RLK- and NLR-mediated signalling are connected. Disruption of an immune-activated MEKK1-MKK1/2-MPK4 MAPK cascade activates the NLR SUMM2 via the MAPK kinase kinase MEKK2, leading to autoimmunity4-9. To gain insights into the mechanisms underlying SUMM2 activation, we used an RNA interference-based genetic screen for mekk1 autoimmune suppressors and identified an uncharacterized malectin-like RLK, named LETUM1 (LET1), as a specific regulator of mekk1-mkk1/2-mpk4 autoimmunity via complexing with both SUMM2 and MEKK2. MEKK2 scaffolds LET1 and SUMM2 for protein stability and association, and counter-regulates the F-box protein CPR1-mediated SUMM2 ubiquitination and degradation, thereby regulating SUMM2 accumulation and activation. Our study indicates that malectin-like RLK LET1 senses the perturbance of cellular homoeostasis caused by the deficiency in immune-activated signalling and activates the NLR SUMM2-mediated autoimmunity via MEKK2 scaffolding.
DOI: 10.1038/s41477-020-0748-6
PubMed: 32839517
PubMed Central: PMC7492416
Affiliations:
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R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Fontes, Elizabeth P B" sort="Fontes, Elizabeth P B" uniqKey="Fontes E" first="Elizabeth P B" last="Fontes">Elizabeth P B. 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when="2020">2020</date><idno type="RBID">pubmed:32839517</idno><idno type="pmid">32839517</idno><idno type="doi">10.1038/s41477-020-0748-6</idno><idno type="pmc">PMC7492416</idno><idno type="wicri:Area/Main/Corpus">000066</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000066</idno><idno type="wicri:Area/Main/Curation">000066</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000066</idno><idno type="wicri:Area/Main/Exploration">000066</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding.</title><author><name sortKey="Liu, Jun" sort="Liu, Jun" uniqKey="Liu J" first="Jun" last="Liu">Jun Liu</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Huang, Yanyan" sort="Huang, Yanyan" uniqKey="Huang Y" first="Yanyan" last="Huang">Yanyan Huang</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Kong, Liang" sort="Kong, Liang" uniqKey="Kong L" first="Liang" last="Kong">Liang Kong</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Yu, Xiao" sort="Yu, Xiao" uniqKey="Yu X" first="Xiao" last="Yu">Xiao Yu</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Feng, Baomin" sort="Feng, Baomin" uniqKey="Feng B" first="Baomin" last="Feng">Baomin Feng</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Liu, Derui" sort="Liu, Derui" uniqKey="Liu D" first="Derui" last="Liu">Derui Liu</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Zhao, Baoyu" sort="Zhao, Baoyu" uniqKey="Zhao B" first="Baoyu" last="Zhao">Baoyu Zhao</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Mendes, Giselle C" sort="Mendes, Giselle C" uniqKey="Mendes G" first="Giselle C" last="Mendes">Giselle C. Mendes</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>National Institute of Science and Technology in Plant-Pest Interactions and Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>National Institute of Science and Technology in Plant-Pest Interactions and Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa</wicri:regionArea><wicri:noRegion>Viçosa</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Peiguo" sort="Yuan, Peiguo" uniqKey="Yuan P" first="Peiguo" last="Yuan">Peiguo Yuan</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ge, Dongdong" sort="Ge, Dongdong" uniqKey="Ge D" first="Dongdong" last="Ge">Dongdong Ge</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Wang, Wen Ming" sort="Wang, Wen Ming" uniqKey="Wang W" first="Wen-Ming" last="Wang">Wen-Ming Wang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Fontes, Elizabeth P B" sort="Fontes, Elizabeth P B" uniqKey="Fontes E" first="Elizabeth P B" last="Fontes">Elizabeth P B. Fontes</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Science and Technology in Plant-Pest Interactions and Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>National Institute of Science and Technology in Plant-Pest Interactions and Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa</wicri:regionArea><wicri:noRegion>Viçosa</wicri:noRegion></affiliation></author><author><name sortKey="Li, Pingwei" sort="Li, Pingwei" uniqKey="Li P" first="Pingwei" last="Li">Pingwei Li</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Shan, Libo" sort="Shan, Libo" uniqKey="Shan L" first="Libo" last="Shan">Libo Shan</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="He, Ping" sort="He, Ping" uniqKey="He P" first="Ping" last="He">Ping He</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA. pinghe@tamu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA. pinghe@tamu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">Nature plants</title><idno type="eISSN">2055-0278</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The innate immune system detects pathogen-derived molecules via specialized immune receptors to prevent infections<sup>1-3</sup>. Plant immune receptors include cell surface-resident pattern recognition receptors (PRRs, including receptor-like kinases (RLKs)), and intracellular nucleotide-binding domain leucine-rich repeat proteins (NLRs). It remains enigmatic how RLK- and NLR-mediated signalling are connected. Disruption of an immune-activated MEKK1-MKK1/2-MPK4 MAPK cascade activates the NLR SUMM2 via the MAPK kinase kinase MEKK2, leading to autoimmunity<sup>4-9</sup>. To gain insights into the mechanisms underlying SUMM2 activation, we used an RNA interference-based genetic screen for mekk1 autoimmune suppressors and identified an uncharacterized malectin-like RLK, named LETUM1 (LET1), as a specific regulator of mekk1-mkk1/2-mpk4 autoimmunity via complexing with both SUMM2 and MEKK2. MEKK2 scaffolds LET1 and SUMM2 for protein stability and association, and counter-regulates the F-box protein CPR1-mediated SUMM2 ubiquitination and degradation, thereby regulating SUMM2 accumulation and activation. Our study indicates that malectin-like RLK LET1 senses the perturbance of cellular homoeostasis caused by the deficiency in immune-activated signalling and activates the NLR SUMM2-mediated autoimmunity via MEKK2 scaffolding.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32839517</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2055-0278</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>09</Month></PubDate></JournalIssue><Title>Nature plants</Title><ISOAbbreviation>Nat Plants</ISOAbbreviation></Journal><ArticleTitle>The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding.</ArticleTitle><Pagination><MedlinePgn>1106-1115</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41477-020-0748-6</ELocationID><Abstract><AbstractText>The innate immune system detects pathogen-derived molecules via specialized immune receptors to prevent infections<sup>1-3</sup>. Plant immune receptors include cell surface-resident pattern recognition receptors (PRRs, including receptor-like kinases (RLKs)), and intracellular nucleotide-binding domain leucine-rich repeat proteins (NLRs). It remains enigmatic how RLK- and NLR-mediated signalling are connected. Disruption of an immune-activated MEKK1-MKK1/2-MPK4 MAPK cascade activates the NLR SUMM2 via the MAPK kinase kinase MEKK2, leading to autoimmunity<sup>4-9</sup>. To gain insights into the mechanisms underlying SUMM2 activation, we used an RNA interference-based genetic screen for mekk1 autoimmune suppressors and identified an uncharacterized malectin-like RLK, named LETUM1 (LET1), as a specific regulator of mekk1-mkk1/2-mpk4 autoimmunity via complexing with both SUMM2 and MEKK2. MEKK2 scaffolds LET1 and SUMM2 for protein stability and association, and counter-regulates the F-box protein CPR1-mediated SUMM2 ubiquitination and degradation, thereby regulating SUMM2 accumulation and activation. Our study indicates that malectin-like RLK LET1 senses the perturbance of cellular homoeostasis caused by the deficiency in immune-activated signalling and activates the NLR SUMM2-mediated autoimmunity via MEKK2 scaffolding.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jun</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-9272-9602</Identifier><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Yanyan</ForeName><Initials>Y</Initials><Identifier Source="ORCID">0000-0001-7688-0997</Identifier><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kong</LastName><ForeName>Liang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Xiao</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Baomin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Derui</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Baoyu</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mendes</LastName><ForeName>Giselle C</ForeName><Initials>GC</Initials><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Institute of Science and Technology in Plant-Pest Interactions and Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Peiguo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ge</LastName><ForeName>Dongdong</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Wen-Ming</ForeName><Initials>WM</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fontes</LastName><ForeName>Elizabeth P B</ForeName><Initials>EPB</Initials><Identifier Source="ORCID">0000-0002-7986-1369</Identifier><AffiliationInfo><Affiliation>National Institute of Science and Technology in Plant-Pest Interactions and Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Pingwei</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0002-1815-3107</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shan</LastName><ForeName>Libo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plant Pathology & Microbiology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Ping</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0002-5926-8349</Identifier><AffiliationInfo><Affiliation>Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX, USA. pinghe@tamu.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA. pinghe@tamu.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 GM092893</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 GM097247</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Plants</MedlineTA><NlmUniqueID>101651677</NlmUniqueID><ISSNLinking>2055-0278</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2021</Year><Month>02</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Ge</name><name sortKey="He, Ping" sort="He, Ping" uniqKey="He P" first="Ping" last="He">Ping He</name><name sortKey="He, Ping" sort="He, Ping" uniqKey="He P" first="Ping" last="He">Ping He</name><name sortKey="Huang, Yanyan" sort="Huang, Yanyan" uniqKey="Huang Y" first="Yanyan" last="Huang">Yanyan Huang</name><name sortKey="Huang, Yanyan" sort="Huang, Yanyan" uniqKey="Huang Y" first="Yanyan" last="Huang">Yanyan Huang</name><name sortKey="Kong, Liang" sort="Kong, Liang" uniqKey="Kong L" first="Liang" last="Kong">Liang Kong</name><name sortKey="Kong, Liang" sort="Kong, Liang" uniqKey="Kong L" first="Liang" last="Kong">Liang Kong</name><name sortKey="Li, Pingwei" sort="Li, Pingwei" uniqKey="Li P" first="Pingwei" last="Li">Pingwei Li</name><name sortKey="Liu, Derui" sort="Liu, Derui" uniqKey="Liu D" first="Derui" last="Liu">Derui Liu</name><name sortKey="Liu, Derui" sort="Liu, Derui" uniqKey="Liu D" first="Derui" last="Liu">Derui Liu</name><name sortKey="Liu, Jun" sort="Liu, Jun" uniqKey="Liu J" first="Jun" last="Liu">Jun Liu</name><name sortKey="Mendes, Giselle C" sort="Mendes, Giselle C" uniqKey="Mendes G" first="Giselle C" last="Mendes">Giselle C. Mendes</name><name sortKey="Mendes, Giselle C" sort="Mendes, Giselle C" uniqKey="Mendes G" first="Giselle C" last="Mendes">Giselle C. Mendes</name><name sortKey="Shan, Libo" sort="Shan, Libo" uniqKey="Shan L" first="Libo" last="Shan">Libo Shan</name><name sortKey="Shan, Libo" sort="Shan, Libo" uniqKey="Shan L" first="Libo" last="Shan">Libo Shan</name><name sortKey="Yu, Xiao" sort="Yu, Xiao" uniqKey="Yu X" first="Xiao" last="Yu">Xiao Yu</name><name sortKey="Yu, Xiao" sort="Yu, Xiao" uniqKey="Yu X" first="Xiao" last="Yu">Xiao Yu</name><name sortKey="Yuan, Peiguo" sort="Yuan, Peiguo" uniqKey="Yuan P" first="Peiguo" last="Yuan">Peiguo Yuan</name><name sortKey="Yuan, Peiguo" sort="Yuan, Peiguo" uniqKey="Yuan P" first="Peiguo" last="Yuan">Peiguo Yuan</name><name sortKey="Zhao, Baoyu" sort="Zhao, Baoyu" uniqKey="Zhao B" first="Baoyu" last="Zhao">Baoyu Zhao</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Yanyan" sort="Huang, Yanyan" uniqKey="Huang Y" first="Yanyan" last="Huang">Yanyan Huang</name></noRegion><name sortKey="Wang, Wen Ming" sort="Wang, Wen Ming" uniqKey="Wang W" first="Wen-Ming" last="Wang">Wen-Ming Wang</name></country><country name="Brésil"><noRegion><name sortKey="Mendes, Giselle C" sort="Mendes, Giselle C" uniqKey="Mendes G" first="Giselle C" last="Mendes">Giselle C. Mendes</name></noRegion><name sortKey="Fontes, Elizabeth P B" sort="Fontes, Elizabeth P B" uniqKey="Fontes E" first="Elizabeth P B" last="Fontes">Elizabeth P B. Fontes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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